Introduction: Anabolic steroids are the main causes of doping. Long-term use of high doses of anabolic steroids abuse decreased kidney function and kidney impairment is increasing. The aim of this study was to investigate the effect of anabolic steroid with or without obligatory swim exercise-induced biochemical changes in the kidney tissue of male Wistar rats.
Methodology: 24 male Wistar rats with an average weight of 220±20 g were selected. Animals were divided into four groups controls, nandrolone decanoate, nandrolone, with swimming, swimming alone. Group nandrolone three times a week, each time 10 mg/kg for 6 weeks received nandrolone. Nandrolone decanoates with swimming group received same amount of additional nandrolone, half an hour swimming by weight 15 g. Group swimming alone were doing half an hour obligatory swim with weights of 15 g.
Results: Our study showed that nandrolone with or without obligatory swimming and swimming exercise alone significantly reduced the level of creatinine clearance, urine creatinine and urea compared to the control group. Also use nandrolone with obligatory swimming and swimming exercise alone increased serum creatinine and use nandrolone with or without obligatory swimming increased serum urea.
Discussion: Animal models and human studies show that the use of nandrolone has harmful effects on the kidneys as increased levels of plasma urea and creatinine and other damages in different parts of the kidney. Results of the study showed that intramuscular injections of nandrolone increases serum urea and serum creatinine and nandrolone decanoate injection groups with swimming and swimming exercise alone compared to the control group which Resulting in the highest level of biochemical parameters of kidney function, which is probably due to better absorption.