Introduction: The most common side problems caused by chemotherapy are stress and inflammation that are required to inhibit the effects of non-pharmacological factors. Studies show saffron antioxidant activity, anti-inflammatory and anticancer there.
Methods: The subjects of this study consisted of 50 female volunteers with breast cancer (mean age 4±38 years, weigh 5±78 kg, body fat 3±16 percent) in stage 3 disease and the study of tamoxifen was used . The subjects were randomly divided into 4 groups: control, water exercise, aquatic exercise + supplement of saffron and saffron supplements were divided. Combined subjects saffron and saffron received 3000 mg daily for 8 weeks. The training program in water at 50 to 75 percent savings heart rate was in the pool. Dual multiplied by multiplying the systolic pressure, heart rate was calculated. Levels of malondialdehyde were also measured by ELISA.
Results: Analysis of variance showed a significant difference between the interventions in each of the variables considered in the study. Tukey test showed that compared with the control group indices amount of pressure (P=0.036) and time to exhaustion (P = 0.009) in the group exercises and changes of heart rate following the implementation of the modified Bruce Test, time to exhaustion (P=0.05) and malondialdehyde levels in combination group was statistically significant. Also, Tukey test results showed that compared to the combination, the only difference in levels of malondialdehyde (P=0.023) in the supplement group were significantly different.
Disscusion: Supplementation with saffron water either alone or workout heart rate and resting systolic blood pressure, the product of the dual (DP) and the levels of malondialdehyde (MDA) reduces the time to exhaustion and maximum heart rate following the implementation of the modified Bruce test increases, the effect of the combination approach (workout + supplement) was more meaningful than any of the individual approaches. The results show that non-drug approaches such as saffron supplements and exercise in water by reducing inflammation and cellular stress may improve the quality of life in patients with breast cancer have a role.