Introduction: Cancer is a deadly disease in today's society due to uncontrolled division of abnormal cells in the colony of deformed arise. Among the types of cancer, breast cancer as a deadly disease is prevalent. The present study investigated interval training on the expression of P53 and Bax in the tumor tissue of mice with breast cancer.
Methodology: A total of 6 mice (Balb/c) of 5 to 6 weeks, mean body mass 17 g were randomly divided into two groups: the first group (cancer- training), group two (cancer-no training). To induce cancer, cell line 4T1 cells were used through injection. Medium intensity interval training protocol was carried out for 12 weeks, five sessions in a week, as well as incremental test was used to determine the appropriate training intensity. 48 hours after the last training session, the mice were sacrificed to measure variables. Expression of apoptosis included P53 and Bax in the tumor tissue of mice with breast cancer were examined by quantitative real-time. To determine the significance of differences between variables independent t-test was used.
Results: The increase of both P53 and Bax genes expression in experimental group compared to the control was observed, however, only results in increased Bax protein in the exercise group compared to the control group (P <0.05) was significant.
Discussion: Based on the results of this study, it can be concluded that the implementation of long-term interval training leads to increased apoptosis in the tumor tissue which can be used as a positive mechanism to be considered in the treatment and prevention of tumor growth.