Introduction: The abuse of anabolic steroids to increase concerns about the harmful effects of drugs on different organs has increased. Major concerns related to important changes in various systems of the body including the kidneys, liver, cardiovascular, hormonal system,Reproduction of mental status occurs. This study aimed to determine the effect of nandrolone with or without forced swimming exercise on general changes in renal tissue was performed kidney of male rats.
Methodology: This study was conducted based on experimental design. The study sample consisted of 32 male rats Wistar with an average weight of 220±20 g in the form of four groups of nandrolone alone 10 mg/kg (n=8), nandrolone and forced swim 10 mg/gr (n=8), forced swim to alone (n=8) and control group (n=8) were divided, for 6 weeks, three times a week by injection of anabolic steroids nandrolone one were treated. In this study, to measure changes in kidney tissues public hematoxylin and eosin staining (H&E) and acid-Schiff (PAS) was used.
Results: The staining of histological inflammation around a lot in different parts of the kidney glomeruli, tubular atrophy, glycogen granules containing inflammation interstitial mononuclear, leukocyte counts among various groups showed that the rate of change Nandrolone decanoate plus exercise groups compared with control groups and exercise was more evident.
Discussion: The use of nandrolone induced tubular atrophy and mononuclear inflammation of the glomeruli, proximal and distal tubules and impaired kidney of male rats is functional and structural changes.