Introduction: The increase of the Inter Cellular Adhesion Molecule-1 and Leptin level in the serum has a significant role in cardio-vascular diseases. The purpose of this research was to study the effect of 8 month aerobic training on the level of Inter Cellular Adhesion Molecule-1 and Leptin in the serum of middle aged females.
Methodology: 25 healthy females without any disease, including cardio-vascular diseases, diabetes, blood pressure, kidney diseases and cancer, were selected in two control group (12 people) and experimental group (13 people) to be tested. The average age of the candidates was 42.53 and the average body mass index was 27.53 The experimental group did the increasing aerobic trainings for 8 weeks, 3 times a week and with the intensity of 50 to 75 percents of maximal heart rate.
Results: The level of Inter Cellular Adhesion Molecule-1 and Leptin hormone was measured in both groups before and after the training session in ELISA method and by standard kit. Noting that the data were normal, they were analyzed in a significant level (P≤ 0.005) by the t-student test.
Discussion: The results taken from this research showed that the level of Inter Cellular Adhesion Molecule-1 and Leptin in the serum reduced significantly after 8 month aerobic training. Therefore, it seems that doing aerobic training causes the reduction of mentioned factors and has a role in the prevention of cardio-vascular diseases.