Introduction: Adrenomedullin (ADM) is a cardio protective peptide with direct and indirect effects on proper cardiovascular structure and function. Cardiac rehabilitation programs have positive effect on cardiovascular adaptation of patients, But the effect of aerobic interval training (AIT) on plasma ADM level after Surgery is not clear .so the purpose of our study was to determine AIT on plasma ADM of patients after coronary artery bypass grafting Surgery (CABG).
Methodology: 24 post CABG patients of heart center hospital of tehran were selected purposive (18 men and 6 women with mean of age 60.32±5.81 year, Height 164.64 ± 9.25 cm, Weight 73.86±14.23 kg, SBP 142.67± 6.49 , DBP 84.5.5.16 mmhg in Seated Position at Rest Situation and Functional Capacity of 7.08±2.49 METs) and then were randomly divided into two groups. Control (C) group (Without training program) and aerobic interval training (AIT). Exercise training program was performed 3 sessions in a week for 8 weeks with intensities 80% to 95% and 65% to 80% of reserve heart rate in high and low intensity intervals in order. 48 hours before and after the first and last session of training program blood sampling, especial kit and Elisa method were used for measuring ADM. Finally, paired sample T test and repeated measures variance tests, were used for analyzing data.
Results: ADM decreased not significantly and significantly in control and training group in order (P=0.090, P<0.001). Also there was a significant difference in ADM variation between two groups (P=0.001).
Discussion: AIT decreases compensatory need to ADM, probably because, it is effective in decrements of blood pressure, afterload of heart and improvement of ventricular contractile after CABG surgery.